Since being a summer research intern at Massachusetts Eye and Ear Infirmary in 1994, I have been involved in research endeavors, mainly clinical but also bench work. I have had the opportunities to work with many principal investigators at different institutions including Emory, Tufts, NYU, multicenter trials like PEDIG (Pediatric Eye Disease Investigation Group) and eROP Cooperative Group (evaluating acute phase ROP), and working between Boston academic institutions over the past 7 years for collaborative research. I have been the principal investigator on a number of studies including vision screening instrumentation, juvenile idiopathic arthritis related uveitis and Down Syndrome. I have received grants from Prevent Blindness America to test vision screeners for children and from Lions Eye Research to conduct a fascinating study on instrument based measurement of the levels of Beta-amyloid in the lenses of people with Down syndrome compared to age matched controls. This instrument could serve as a possible early non-invasive diagnostic test for Alzheimer’s disease.
Teaching has been a focus of my early career and I have had the opportunity to be a part of the Boston Children’s Hospital Teaching Academy. As part of this academy, I have been able to contribute to the improvement of the ophthalmology surgical training program. These improvements include the development of a means for attending’s assessment of trainees, trainee self-assessment and other training tools such as a surgical video instructional library and participation in a new strabismus course and wet-lab. In addition, I lecture the Harvard Medical Students 8 times a year as part of their core medicine block on ophthalmology which serves as the foundation of their knowledge for eye disease, diagnosis and care. Over the past 9 years, I have given almost 90 lectures to medical and nurse practitioner students, residents, fellows, and other physician colleagues including neonatologists, anesthesiologists, primary care physicians, optometrists, and pediatricians. The topics are largely pediatric ophthalmology related such as abusive head trauma, retinopathy of prematurity, pediatric cataract, vision screening, uveitis, and Down syndrome eye conditions. I have had the opportunity to participate in national and international meetings including an international strabismus symposium in Nepal and the second world congress of pediatric ophthalmology and strabismus in Milan, Italy where I presented on the use of TNF-alpha inhibitors in JIA-related uveitis.
1.) Foster CS, Ledoux D. Types and Management of Ophthalmic Herpes Simplex Virus
Infections. Herpes 1995; 2(1): 27-32.
2.) Dutt JE, Ledoux D, Baer H, Foster CS. Collagen Abnormalities in Conjunctiva of Patients with Cicatricial Pemphigoid. Cornea 1996; 15(6): 606-611.
3.) Fouladvand M, Ledoux DM, Barton JJS. Ocular Myasthenia Gravis. Comprehensive Ophthalmology Update 2005; 6(1): 25-36.
4.) Ledoux DM, Trivedi RH, Wilson ME, Payne JH. Pediatric cataract extraction with intraocular lens implantation: Visual acuity outcome when measured at age four years and older. J AAPOS 2007; 11(3): 218-224.
5.) Ledoux DM. What’s your diagnosis? Juvenile Xanthogranuloma of the iris. J Pediatr Ophthalmol Strabismus. 2008; 45(2): 76.
6.) Pediatric Eye Disease Investigation Group. Balloon Catheter Dilation and Nasolacrimal Duct Intubation for Treatment of Nasolacrimal Duct Obstruction after Failed Probing. Arch Ophthalmol 2009; 127(5): 633-9.
7.) Mehendale RA, Dagi LR, Wu C, Ledoux D, Johnston S, Hunter DG. Superior rectus transposition and medial rectus recession for Duane syndrome and sixth nerve palsy. Arch Ophthalmol. 2012; 130(2): 195-201.
8.) Ledoux DM, Johnston S, Walton DS. Angle surgery: goniotomy and trabeculotomy. In: Kahook M (ed.). Essentials of Glaucoma Surgery. Thorofare, NJ: SLACK Incorporated;2012:260-272.
9.) Schneier AJ, Heidary G, Ledoux DM. Optic Nerve Appearance in Patients with Down Syndrome. J Pediatr Ophthalmol Strabismus. 2013; 50(1): 60.
10.) e-ROP Cooperative Group. Validity of a Telemedicine System for the Evaluation of Acute-Phase Retinopathy of Prematurity. JAMA Ophthalmology 2014; June 26: E1-E7.
11.) e-ROP Cooperative Group. Telemedicine Approach to Evaluating Acute-phase Retinopathy of Prematurity: Study Design. Ophthalmic Epidemiol. 2014 Aug 21(4): 256-67.